This was a road house and inn known known as Four Mile House. Before that it was owned by a man named Francis Prevost, a French immigrant who came to Detroit in 1846, helping build a farm in the "wilds" of Wayne County seven miles from city hall. He lived on that farm until he was 23, when he operated dry goods and wholesaling concerns downtown, and after he lost his holdings to a fire he operated this house as a hotel for ten years and then moved to Saginaw where he started a soft drink company. Four Mile House, located at Crane & Gratiot, was built for a Mrs. Emilia Colquitt in 1862. I could locate no further information about her.
I'm guessing that's a 1933 Ford, so this was taken some time after that.
via the Virtual Motor City Project